[\/et_pb_text][et_pb_text admin_label=\u00a0\u00bbThykamineTM\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_2_text_color=\u00a0\u00bb#1F386B\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb max_width=\u00a0\u00bb100%\u00a0\u00bb custom_margin=\u00a0\u00bb|0px|||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb|0px|||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
Les cosm\u00e9ceutiques repr\u00e9sentent aujourd\u2019hui le segment \u00e0 la croissance la plus rapide de l\u2019industrie des cosm\u00e9tiques et des soins personnels.<\/p>\n
<\/p>\n
On distingue trois principales cat\u00e9gories de produits pour les soins de la peau :<\/p>\n
<\/p>\n
- \n
- Marques de qualit\u00e9 pharmaceutique formul\u00e9es par des dermatologues et des m\u00e9decins<\/li>\n
- Produits de prestige<\/li>\n
- Produits grand public<\/li>\n<\/ul>\n
<\/p>\n
Une tendance cl\u00e9 de l\u2019industrie est que les cosm\u00e9ceutiques les plus prometteurs sont ceux qui reposent sur des donn\u00e9es scientifiques solides.
Tous les produits de soins de la peau de Devonian sont d\u00e9velopp\u00e9s selon la m\u00eame approche scientifique que ses m\u00e9dicaments pharmaceutiques.
Appuy\u00e9s par des donn\u00e9es probantes de s\u00e9curit\u00e9 et d\u2019efficacit\u00e9, ces produits se positionnent comme de v\u00e9ritables solutions fond\u00e9es sur la science.<\/p>\n<\/p>\n
<\/p>\n
<\/p>\n
R-SpinasomeMD<\/sup> : un ingr\u00e9dient actif cosm\u00e9ceutique r\u00e9volutionnaire<\/h2>\n
<\/p>\n
R-SpinasomeMD<\/sup>, l\u2019ingr\u00e9dient phare de la gamme cosm\u00e9ceutique de Devonian, est un extrait cellulaire photosynth\u00e9tique compos\u00e9 de pigments, de prot\u00e9ines et de lipides issus de feuilles vertes.
La structure unique de ce complexe est essentielle \u00e0 sa fonction antioxydante : elle lui permet de capturer et de dissiper l\u2019\u00e9nergie nocive g\u00e9n\u00e9r\u00e9e par les esp\u00e8ces r\u00e9actives de l\u2019oxyg\u00e8ne (ROS), puis de se r\u00e9g\u00e9n\u00e9rer pour \u00eatre pr\u00eate \u00e0 recommencer de nouveaux cycles d\u2019activation.<\/p>\n<\/p>\n
C\u2019est cette capacit\u00e9 de r\u00e9g\u00e9n\u00e9ration dynamique qui conf\u00e8re \u00e0 R-SpinasomeMD<\/sup> une activit\u00e9 antioxydante in\u00e9dite et durable.
R-SpinasomeMD <\/sup>est prot\u00e9g\u00e9 par des brevets au Japon, au Canada, aux \u00c9tats-Unis et en Europe
(#JP 5952261; #CDN 2,699,6765; #US 13\/261,472, #EUR 11 768 299.7).<\/a><\/p>\n<\/p>\n
<\/p>\n
<\/p>\n
PurgenesisMC <\/sup>: une gamme novatrice de produits anti-\u00e2ge<\/h2>\n
<\/p>\n
La premi\u00e8re ligne dermocosm\u00e9ceutique d\u00e9velopp\u00e9e par Devonian est une gamme de produits anti-\u00e2ge pour femmes, comprenant des cr\u00e8mes de jour, de nuit et pour le contour des yeux.
Ces formulations exclusives contiennent R-SpinasomeMD<\/sup>, l\u2019ingr\u00e9dient actif naturel brevet\u00e9 de Devonian.<\/p>\n<\/p>\n
Dans une \u00e9tude comparative de 28 jours, le traitement PurgenesisMC<\/sup> a d\u00e9montr\u00e9 une efficacit\u00e9 anti-\u00e2ge sup\u00e9rieure \u00e0 celle de deux grandes marques de prestige.
Lors d\u2019une \u00e9tude aupr\u00e8s d\u2019un panel de consommatrices, plus de 75 % des participantes ont indiqu\u00e9 qu\u2019elles remplaceraient leur produit actuel par celui de Devonian.<\/p>\n<\/p>\n
Le traitement anti-\u00e2ge PurgenesisMC<\/sup> a re\u00e7u le Sceau de reconnaissance du Programme de sant\u00e9 de la peau de l\u2019Association canadienne de dermatologie (ACD), \u00e0 la suite d\u2019une \u00e9valuation approfondie de sa formulation par le Conseil consultatif d\u2019experts sur la sant\u00e9 de la peau de l\u2019ACD.<\/p>\n
<\/p>\n
En 2018, le traitement PurgenesisMC<\/sup> a \u00e9t\u00e9 nomm\u00e9 \u00ab Meilleure technologie de traitement anti-\u00e2ge de la peau \u00bb par le magazine britannique LUX Life, soulignant son niveau d\u2019excellence exceptionnel.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00a0\u00bb1_3,1_3,1_3″ _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb max_width=\u00a0\u00bb80%\u00a0\u00bb custom_padding=\u00a0\u00bb||70px||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_3″ _builder_version=\u00a0\u00bb4.16″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3″ _builder_version=\u00a0\u00bb4.16″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_image src=\u00a0\u00bbhttps:\/\/groupedevonian.com\/wp-content\/uploads\/2022\/01\/recognized-skin-health.png\u00a0\u00bb title_text=\u00a0\u00bbrecognized-skin-health\u00a0\u00bb align=\u00a0\u00bbcenter\u00a0\u00bb _builder_version=\u00a0\u00bb4.16″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_3″ _builder_version=\u00a0\u00bb4.16″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_enable_image=\u00a0\u00bboff\u00a0\u00bb background_size=\u00a0\u00bbcontain\u00a0\u00bb background_blend=\u00a0\u00bbsoft-light\u00a0\u00bb max_width=\u00a0\u00bb80%\u00a0\u00bb custom_margin_tablet=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_margin_phone=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_margin_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb0px||||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text admin_label=\u00a0\u00bbPurgenesis\u2122 brand : market ready pipeline of innovative products\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_2_text_color=\u00a0\u00bb#1F386B\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
\n\n\n\nPurgenesis\u2122 : Gamme de produits novateurs<\/h3>\n
La gamme de produits cosm\u00e9ceutiques en d\u00e9veloppement comprend :<\/p>\n
- \n
- S\u00e9rum<\/li>\n
- \n
Cr\u00e8me r\u00e9g\u00e9n\u00e9ratrice<\/p>\n<\/li>\n<\/ul>\n
Pour obtenir de plus amples renseignements sur les produits Purgenesismc<\/sup><\/strong>, veuillez consulter www.purgenesis.com<\/a><\/p>\n<\/div>\n
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[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1″ _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bb#f4f4f4″ custom_padding=\u00a0\u00bb100px||80px||false|false\u00a0\u00bb top_divider_color=\u00a0\u00bb#1B303B\u00a0\u00bb top_divider_height=\u00a0\u00bb50px\u00a0\u00bb bottom_divider_color=\u00a0\u00bb#1B303B\u00a0\u00bb bottom_divider_height=\u00a0\u00bb50px\u00a0\u00bb bottom_divider_flip=\u00a0\u00bbhorizontal\u00a0\u00bb custom_css_main_element=\u00a0\u00bbbackground: url(\/wp-content\/uploads\/2025\/11\/dots-br.png)\/*, url(\/wp-content\/uploads\/2025\/11\/lines-bl.png)*\/, url(\/wp-content\/uploads\/2025\/11\/dots-tl.png)\/*, url(\/wp-content\/uploads\/2025\/11\/lueur-bl-v2.png)*\/ !important;||background-repeat: no-repeat !important;||background-position: right bottom,\/* left bottom,*\/ left top\/*, left bottom*\/ !important;||background-size: auto !important;\u00a0\u00bb locked=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb custom_css_main_element_last_edited=\u00a0\u00bbon|desktop\u00a0\u00bb custom_css_main_element_tablet=\u00a0\u00bbbackground: url(\/wp-content\/uploads\/2025\/11\/dots-br.png)\/*, url(\/wp-content\/uploads\/2025\/11\/lines-bl.png)*\/, url(\/wp-content\/uploads\/2025\/12\/dot-top-right.png)\/*, url(\/wp-content\/uploads\/2025\/11\/lueur-bl-v2.png)*\/ !important;||background-repeat: no-repeat !important;||background-position: right bottom\/*, left bottom*\/, right top\/*, left bottom *\/ !important;||background-size: auto !important;\u00a0\u00bb custom_css_main_element_phone=\u00a0\u00bbbackground: url(\/wp-content\/uploads\/2025\/11\/dots-br.png)\/*, url(\/wp-content\/uploads\/2025\/11\/lines-bl.png)*\/, url(\/wp-content\/uploads\/2025\/12\/dot-top-right.png)\/*, url(\/wp-content\/uploads\/2025\/11\/lueur-bl-v2.png)*\/ !important;||background-repeat: no-repeat !important;||background-position: right bottom\/*, left bottom*\/, right top\/*, left bottom *\/ !important;||background-size: auto !important;\u00a0\u00bb][et_pb_row custom_padding_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_enable_image=\u00a0\u00bboff\u00a0\u00bb background_size=\u00a0\u00bbcontain\u00a0\u00bb background_blend=\u00a0\u00bbsoft-light\u00a0\u00bb max_width=\u00a0\u00bb80%\u00a0\u00bb custom_margin_tablet=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_margin_phone=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_margin_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb0px||||false|false\u00a0\u00bb filter_hue_rotate=\u00a0\u00bb-30deg\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text admin_label=\u00a0\u00bbReferences\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_2_text_color=\u00a0\u00bb#1F386B\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb max_width=\u00a0\u00bb100%\u00a0\u00bb custom_margin=\u00a0\u00bb|0px|||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb|0px|||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
R\u00e9f\u00e9rences<\/h2>\n
<\/p>\n
- \n
- Carroll JM, Hanna S, Guenther LC, Boucher N. Comparison of topical antiaging creams in the management of lateral canthal lines. J Cosmet Dermatol. 2020 Mar;19(3):694-704. doi: 10.1111\/jocd.13062. Epub 2019 Jul 26. PMID: 31350814; PMCID:\u00a0
Link: https:\/\/pubmed.ncbi.nlm.nih.gov\/31350814\/<\/a><\/li>\n<\/ol>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1″ custom_padding_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_image=\u00a0\u00bbhttps:\/\/groupedevonian.com\/wp-content\/uploads\/2025\/11\/cta-targeted.png\u00a0\u00bb custom_padding=\u00a0\u00bb174px||174px||true|\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb174px||174px||true|\u00a0\u00bb custom_padding_phone=\u00a0\u00bb|24px||24px|true|true\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width=\u00a0\u00bb90%\u00a0\u00bb max_width=\u00a0\u00bb90%\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text admin_label=\u00a0\u00bbWould you like to know more about our Purgenesis Cosmeceuticals?\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_text_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb header_2_font_size=\u00a0\u00bb38px\u00a0\u00bb header_3_text_align=\u00a0\u00bbcenter\u00a0\u00bb header_3_text_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb header_3_font_size=\u00a0\u00bb30px\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb max_width=\u00a0\u00bb1080px\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
Voulez vous en savoir plus sur nos Therapeutiques?<\/h3>\n
[\/et_pb_text][et_pb_button button_url=\u00a0\u00bb@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjEyNTkifX0=@\u00a0\u00bb button_text=\u00a0\u00bbEn savoir plus\u00a0\u00bb button_alignment=\u00a0\u00bbcenter\u00a0\u00bb admin_label=\u00a0\u00bbButton – Learn more\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _dynamic_attributes=\u00a0\u00bbbutton_url\u00a0\u00bb _module_preset=\u00a0\u00bbdefault\u00a0\u00bb filter_saturate=\u00a0\u00bb-190%\u00a0\u00bb filter_brightness=\u00a0\u00bb-110%\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1″ custom_padding_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bb#FFFFFF\u00a0\u00bb custom_padding=\u00a0\u00bb180px||240px||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb120px||120px||false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb||||false|false\u00a0\u00bb top_divider_color=\u00a0\u00bb#1F376D\u00a0\u00bb top_divider_flip=\u00a0\u00bbhorizontal\u00a0\u00bb bottom_divider_style=\u00a0\u00bbwave\u00a0\u00bb bottom_divider_color=\u00a0\u00bb#1F386B\u00a0\u00bb bottom_divider_height=\u00a0\u00bb50px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb4.17.3″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.16″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text admin_label=\u00a0\u00bbDevonian\u2019s technology…\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_3_text_align=\u00a0\u00bbcenter\u00a0\u00bb header_3_text_color=\u00a0\u00bb#1F386B\u00a0\u00bb header_3_line_height=\u00a0\u00bb1.2em\u00a0\u00bb background_enable_color=\u00a0\u00bboff\u00a0\u00bb text_orientation=\u00a0\u00bbcenter\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n
La technologie de Devonian repose sur une plateforme scientifique \u00e9tendue, mise au point au fil de plus de quinze ann\u00e9es de recherche.<\/h3>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Produits cosm\u00e9ceutiquesLes cosm\u00e9ceutiques repr\u00e9sentent aujourd\u2019hui le segment \u00e0 la croissance la plus rapide de l\u2019industrie des cosm\u00e9tiques et des soins personnels.On distingue trois principales cat\u00e9gories de produits pour les soins de la peau : Marques de qualit\u00e9 pharmaceutique formul\u00e9es par des dermatologues et des m\u00e9decins Produits de prestige Produits grand public Une tendance cl\u00e9 de […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":2201,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"
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[cherry_tabs style=\"default\" active=\"1\" vertical=\"yes\"]<\/p>
[cherry_tab title=\"Purgenesis Cosmeceuticals\" anchor=\"Purgenesis Cosmeceuticals\"]<\/p>
PurgenesisTM<\/sup> Cosmeceuticals<\/h2>
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\u00a0<\/p>
Cosmeceuticals have become the fastest-growing segment of the cosmetics and personal care industry.<\/p>
There are three different categories of skin care products:<\/p>
- \u201cpharma-quality\u201d dermatologist\/physician formula brands;
- prestige products; and
- mass-market products.<\/p>A trend is that the cosmeceutical products with the best potential will be those that are backed by science.<\/p>
All of Devonian\u2019s<\/span><\/strong> skin-care products are developed by the same approach as its\u00a0pharmaceutical products, with strong safety and efficacy data, which positions these products as science-based.<\/p>
The first derma-cosmeceutical product that\u00a0Devonian<\/strong>\u00a0has developed is a women\u2019s anti-aging treatment consisting of day, night, and eye creams. R-Spinasome\u2122,\u00a0Devonian\u2019s<\/strong>\u00a0proprietary natural active ingredient is included in this market-ready product to be marketed under the Purgenesistm<\/sup> brand. The PurgenesisTM<\/sup> treatment now carries the seal of recognition of the Skin Health Program, awarded after a thorough review of the treatment formulation by the Canadian Association of Dermatology's Expert Advisory Council on Skin Health. This product is patent pending in several countries.<\/p>
\u00a0<\/p>
![\"\"](\"https:\/\/groupedevonian.com\/wp-content\/uploads\/2017\/09\/bi-black-300x124.png\")
<\/p>Devonian's strategy<\/h3>
\u00a0<\/p>
Devonian<\/span><\/strong> intends to market it under PurGenesis\u2122 brand or as a private label with marketing partners.<\/p>
For more information on Derma-cosmeceutical products, please click here<\/strong><\/a><\/p>
\u00a0<\/p>
![\"tech2-11\"](\"https:\/\/groupedevonian.com\/\/wp-content\/uploads\/2017\/04\/tech2-11_v2017.jpg\")
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[\/cherry_tab]<\/p>[cherry_tab title=\"Therapeutics\" anchor=\"Therapeutics\"]<\/p>
Therapeutics<\/h2>
\u00a0<\/p>
[cherry_spacer size=\"17\"]<\/p>
Thykamine\u2122<\/h3>
Thykamine\u2122<\/strong>\u00a0is an active lead drug candidate with excellent safety and efficacy profiles confirmed in several pre-clinical and cinical studies targeting inflammation.<\/p>
In Phase 2a, the Corporation conducted a clinical trial: a 2-week, exploratory randomized, double-blind, parallel-group, dose-ranging, placebo-controlled safety, tolerability, biomarker and efficacy clinical study of Thykamine\u2122<\/strong>\u00a0<\/sup>\u00a0 rectal enema in patients with active mild-to-moderate distal ulcerative colitis.<\/p>
The primary objective of the study was met. Administration of 250 mg, 500 mg and 1000 mg doses of Thykamine\u2122<\/strong>\u00a0<\/sup>\u00a0rectal enema once daily was safe and well tolerated in subjects with active mild-to-moderate distal ulcerative colitis. There was a statistically significant (p<0.05) reduction in the mean change from baseline in the rectal bleeding sub-score of the modified Mayo score, a cardinal symptom\/sign of ulcerative colitis, for the Thykamine\u2122<\/strong>\u00a0<\/sup>\u2013 250 mg dose compared to placebo at Endpoint\/Day 14.<\/p>
Among the biomarkers, there was a statistically significant reductions in the fecal lactoferrin (FL) levels, a biomarker with high specificity and sensitivity to detect intestinal inflammation, in serum Transforming Growth Factor-beta (TGF-b) and serum M-30 apoptosome.<\/p>
The objective evidence of activity as per the biomarkers' reductions and the clinical assessment\u2019s results of the clinical study together have demonstrated the biological activity of Thykamine\u2122<\/strong>\u00a0rectal enema in patients with active mild-to-moderate distal ulcerative colitis within a very short treatment duration.<\/p>
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Indications currently being pursued with Thykamine\u2122<\/h3>
ATOPIC DERMATITIS<\/strong><\/p>
Atopic Dermatitis (Eczema) is a chronic, relapsing inflammatory skin disease characterized by itchy skin lesions and rashes. Although this condition affects people of all ages, it is most common among infants and children. In general, the prevalence of atopic dermatitis is increasing worldwide and is higher in developed nations than in other parts of the world.<\/p>
Prevalence:\u00a0<\/strong>Atopic Dermatitis affects 15 to 30% of children and 2 to 10% of adults worldwide. It is associated with co-occuring disorders such as asthma, rhinitis, food allergies and bacterial infections. Quality of Life of the patient and family can be impaired. It is estimated that Atopic Dermatitis affects\u00a0 9 to 30 percent of people in United States.<\/p>
Development Stage:\u00a0<\/strong>Devonian<\/span><\/strong> will initiate a Phase 2 clinical study in Q2-2017 and complete it in Q1\u20112018. This will be a double-blind, placebo-controlled study of topical Thykamine\u2122<\/strong>\u00a0in patients with mild-to-moderate atopic dermatitis.<\/p>
ULCERATIVE COLITIS<\/strong><\/p>
Ulcerative colitis\u00a0(UC) is a chronic relapsing form of\u00a0inflammatory bowel disease<\/a> that causes inflammation and ulcers in the\u00a0colon<\/a>. Symptoms can range from mild to severe with disease onset usually occurring in young adults. Intermittent\u00a0rectal bleeding<\/a>, crampy\u00a0abdominal pain<\/a>\u00a0and\u00a0diarrhea<\/a>\u00a0often are\u00a0symptoms of ulcerative colitis<\/a>. Its course is unpredictable but with a strong likelihood of life-long disease. It can be debilitating and sometimes can lead to life-threatening complications.<\/p>
Prevalence: <\/strong>The disease is more common in northern regions of the world.\u00a0Approximately 238 of 100,000 adults are affected\u00a0 by ulcerative colitis. It is estimated that up to 2 million people are affected in United States.<\/p>
Development Stage:\u00a0<\/strong>Devonian<\/span><\/strong> has plans for a larger Phase 2b clinical trial and of longer treatment duration: a 12\u2011week, randomized, double\u2011blind, parallel-group, dose-ranging, placebo-controlled efficacy, safety and tolerability study of Thykamine\u2122<\/strong>\u00a0rectal enema to treat patients with active mild-to-moderate distal ulcerative colitis. Devonian<\/span><\/strong> intends to request a meeting with the FDA by the end of 2017. The meeting will allow Devonian<\/span><\/strong> to submit to the FDA the results of the in vitro<\/em> and in vivo<\/em> pharmacology studies, the safety pharmacology and toxicology studies, and the results of the Phase 1 and 2a clinical studies along with the clinical trial protocol of the planned Phase 2b study. Management believes that the safety and efficacy profile of\u00a0Thykamine\u2122<\/strong> demonstrated in all the former studies should provide justification for the FDA to allow Devonian<\/span><\/strong> to proceed with the Phase 2b clinical trial without any safety issues.<\/p>
- Carroll JM, Hanna S, Guenther LC, Boucher N. Comparison of topical antiaging creams in the management of lateral canthal lines. J Cosmet Dermatol. 2020 Mar;19(3):694-704. doi: 10.1111\/jocd.13062. Epub 2019 Jul 26. PMID: 31350814; PMCID:\u00a0
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